Synthetic Methods for the Preparation of Novel α-Aminophosphonates and β-Aminophosphonates using N-Heterocyclicphosphine-thioureas (NHP-thiourea) and the Synthesis of the 2nd generation of NHPs


Novel cost-effective, metal-free synthetic method for β-aminophosphonates and α-aminophosphonates.

The Invention

This technology is a novel synthetic method towards β-aminophosphonates and α-aminophosphonates which are commonly found in pharmaceuticals and biologically active compounds. These are produced by using N-heterocyclicphosphine-thioureas (NHP-thiourea). This synthesis allows the formation of a P-C bond under metal-free, mild conditions.

Key Benefits

  • Metal-free synthesis
  • “Green Reaction” (reduces use of hazardous substances)
  • Reaction can be completed under mild conditions
  • Cost-effective
  • Environmentally friendly


  • Pharmaceutical
  • Medicinal chemistry
  • Agrochemistry

rket Opportunity

β-aminophosphonates and α-aminophosphonates are used as reagents to synthesize various phosphonates. Thus, they have several markets including active pharmaceutical ingredients, specialty chemical, and pesticide manufacturing.

The active pharmaceutical ingredients global market was $299.2 billion in 2020 and is forecasted to grow by a CAGR of 7.98% to $521.1 billion by 2030. The specialty chemical global market size was $588.2 billion in 2020 and is expected to grow at a CAGR of

6.17% up to $894.1 billion by 2028. The U.S. pesticide manufacturing market is currently $16.8 billion and is expected to grow at a CAGR of 1.4% to $17.9 billion by 2028.

In pharmaceutical industries, removal of impurities is a challenging task and significantly related to the price of drugs. Although this green method may be slower than other methods, it is a less hazardous cost-effective method.

Development and Intellectual Property Status

29 novel-aminophosphonates were synthesized using this method. Proof-of-principal has been performed with α-aminophosphonates, with the intention of screening various

substituted aziridines to explore the scope of electrophiles. Preliminary data suggests the synthesis of 2nd generation NHPs should be possible.

Patent Information:
For Information, Contact:
John Minnick
Business Development Officer
University of Nevada, Las Vegas
Jun Yong Kang
Karimulla Mulla
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